安三奇教授

安三奇

教授，博士生导师

广西医科大学高层次引进人才

广西医科大学杰出青年人才

地址：广西南宁市双拥路22号，530021

电话：0771-5358177

Email：ansq@mail2.sysu.edu.cn

个人简历

安三奇，理学博士，教授，博士生导师。担任Briefings in bioinformatics，Molecular Therapy - Nucleic Acids等十余个国际知名期刊的特约审稿专家和青年编委。2020年获得中山大学中山医学院分子医学博士学位。入选2020年广西医科大学高层次引进人才，2022年广西医科大学杰出青年人才。作为项目负责人主持国家自然科学基金在内的各类研究课题5项。主要研究领域为医学生物信息学，通过收集RNA转录组学数据并分析，揭示复杂疾病中的RNA转录调控新调控理论，新机制和新的治疗靶点。目前已经在m6A的RNA甲基化领域做出了有一定国际影响力的工作。近5年时间，利用公共数据库以第一作者或通讯作者在Nucleic Acids Research, Oncogene, Genes and Diseases, Genomics, Proteomics & Bioinformatics等重要期刊等发表十余项成果。研究成果在领域内得到了关注，发表的论文曾被列为世界学术组织“Faculty Opinions (原F1000Prime)”列为推荐论文。也被重要期刊的论文多次正面引用。

主持的科研项目情况：

1.国家自然科学基金地区项目，82160389，CAPRIN1通过特异性调控干扰素刺激基因的m6A修饰进而促进MTB感染的机制研究，2022/1/1-2025/12/31，34万，在研，主持

2. 广西科技基地和人才专项项目, 2022AC19006, 泛癌中m6A的分子图谱特征以及生物学调控网络研究, 2022/09-2025/8, 20万，在研，主持

3. 中国博士后科学基金面上项目二等, 2018M683623XB, m6A阅读器蛋白IGF2BPs对感染COVID-19的癌症患者的进程影响和功能机制研究, 2021/10-2022/09, 9万元，已结题，主持

代表性论文：

(1) Sanqi An#, Wanxu Huang#, Xiang Huang#, Yixian Cun, Weisheng Cheng, Xiang Sun, Zhijun Ren, Yaxin Chen, Wenfang Chen, Jinkai Wang*. Integrative network analysis identifies cell-specific trans regulators of m6A. Nucleic Acids Research, January 2020, 48(4).

(2) Sanqi An#, Yueqi Li#, Yao Lin#, Jiemei Chu, Jinming Su, Qiuli Chen, Hailong Wang, Peijiang Pan, Ruili Zheng, Jingyi Li, Junjun Jiang*, Li Ye*, Hao Liang*. Ge-nome-Wide Profiling Reveals Alternative Polyadenylation of Innate Immune-Related mRNA in Patients With COVID-19. Frontiers in Immunology, October 2021, 12.

(3) Sanqi An#，Zhouhua Xie#, Yanyan Liao#, Junjun Jiang#, Wenyi Dong, Fuqiang Yin, Wenxing Li*,Li Ye*, Jianyan Lin*, Hao Liang*. Systematic analysis of clinical relevance and molecular characterization of m6A in COVID-19 patients. Genes & Diseases 4, January 2022, 9(5).

(4) Yaxin Chen#, Gang Wang#, Jingyi Li, Lei Xia, Lin Zhu, Wenxing Li, Qiang Luo, Yinlu Liao, Yao Lin, Liyun Bi, Hubin Chen, Jiemei Chu, Yueqi Li, Jinming Su, Li Ye, Junjun Jiang, Hao Liang*, Weimin Li* and Sanqi An*. CASA: a comprehensive da-tabase resource for the COVID-19 Alternative Splicing Atlas. Journal of Translational Medicine. 20;20(1):473. 2022.

(5) Lin Yao#，Li Yueqi#，Chen Hubin#，Meng Jun，Li Jingyi，Chu Jiemei，Zheng Ruili，Wang Hailong，Pan Peijiang，Su Jinming，Jiang Junjun，Ye Li，Liang Hao，An Sanqi*. Weighted gene co-expression network analysis revealed T cell differentiation associated with the age-related phenotypes in COVID-19 pa-tients. BMC Medical Genomics 2023.

(6) Sanqi An#, Ke He#, Fei Liu, Qianshan Ding, Yan-Li Wei, Zhenglin Xia, Xiao-peng Duan, Rui Huang, Bowei Li, Haihe Wang, Yu Tian, Guoan Xiang*, Wenxing Li*. Low microRNA150 expression is associated with activated carcinogenic path-ways and a poor prognosis in patients with breast cancer. Oncology Reports, January 2021, 45(3).

(7) Xiaopeng Hu, Sanqi An*, Jiemei Chu, Bingyu Liang , Yanyan Liao, Junjun Jiang, Yao Lin, Li Ye * and Hao Liang. Potential Inhibitors of Monkeypox Virus Re-vealed by Molecular Modeling Approach to Viral DNA Topoisomerase I. Molecules.

(8) Renchao Zou#, Zhitian Shi#, Shufeng Xiao, Yang Ke, Tiangen Wu, Zhitang Guo, Fan Ni, Sanqi An*, and Lin Wang*. Co-expression analysis and ceRNA network re-veal eight novel potential lncRNA biomarkers in hepatocellular carcinoma. Peer J, 2019.

(9) Wen-Xing Li#, Shao-xing Dai#, Sanqi An#, Tingting Sun#, Justin Liu, Jun Wang, Leyna G Liu, Yang Xun, Hua Yang, Li-Xia Fan, Xiao-Li Zhang, Wan-Qin Liao, Hua You, Luca Tamagnone, Fang Liu, Jingfei Huang, Dahai Liu*. Transcrip-tome integration analysis and specific diagnosis model construction for Hodgkin's lymphoma, diffuse large B-cell lymphoma, and mantle cell lymphoma. Aging, April, 2021 13(8).

(10) Xia Zhou#, Gong-Hua Li#, Sanqi An#, Wenxing Li, Huihui Yang, Yicheng Guo, Dai Zhi, Shaoxing Dai, Junjun Zheng, Jingfei Huang*, Iavarone, A.*, Xudong Zhao*. A new method of identifying glioblastoma subtypes and creation of corresponding animal models. Oncogene, August 2018, 37(35).

专利：

梁浩; 韦吴迪; 蒋俊俊; 王刚; 黄颉刚; 张洪; 安三奇; 梁冰玉; 陈荣凤; 包秀丽; 罗强 ; NCOR2可变剪切体在制备预防或治疗马尔尼菲篮状菌感染的药物中的应用, 2022-04-01, 中国, CN202210338476.0。

软件著作权：

安三奇，李玥琪，褚洁梅，梁浩，韦吴迪，李静怡。李文兴，叶力，蒋俊俊，胡小鹏，王刚。基于m6A调控因子和序列特征的单细胞m6A计算方法软件。2022.10.21（2023SR0365699）。