褚洁梅副教授

褚洁梅

副教授，硕士生导师

地址：广西南宁市双拥路22号，530021

电话：0771-5358129

Email：jmchu@gxmu.edu.cn

个人简历

褚洁梅，理学博士，副教授，硕士生导师，毕业于武汉大学分析化学专业。现在广西医科大学生命科学研究院的代谢组学平台工作，负责基于大型仪器超高效液相色谱和高分辨质谱联用仪的代谢组学检测等工作，同时也是广西艾滋病防治研究重点实验室青年科研人员。主要从事感染性疾病的代谢组学及表观遗传学等多组学研究工作。

主持的科研项目情况：

1.国家自然科学基金青年科学基金项目，81903367，高灵敏质谱探针技术研究RNA修饰在HIV/TM感染中的作用及其机制探索，2020-01-01至2022-12-31, 21万元。

2.中国博士后科学基金面上项目二等，2018M643382，质谱探针技术分析RNA修饰及其在艾滋病研究中的应用，2018-09-01至2020-04-30，5万元。

3. 广西自然科学基金青年科学基金项目, 2018GXNSFBA281014, 基于质谱探针技术的HIV感染与抗HIV过程中RNA修饰动态变化的研究, 2019-01-01至2021-12-31, 9万元。

代表性论文：

(1) Jiemei Chu^#, Ruili Zheng^#, Hubin Chen^#, Yaxin Chen^#, Yao Lin, Jingyi Li, Wudi Wei, Rongfeng Chen, Peixue Deng, Jinming Su, Junjun Jiang, Li Ye*, Hao Liang* and Sanqi An*, Dynamic m6A profiles reveal the role of YTHDC2-TLR2 signaling axis in Talaromyces marneffei infection, Journal of Medical Virology, 2024, 96(2): e29466.

(2) Wenjin Hu, Yiying Huang, Yingjing Liu, Xiaoying Zhou, Shushi Huang, Jiemei Chu*, Xinli Pan*, Novosphingobium beihaiensis sp. nov., a novel pesticide-tolerant bacterium isolated from mangrove sediments, Antonie van Leeuwenhoek, 2023, 116(11): 1151-1159.

(3) Xin Liu^#, Jiemei Chu^#, Chun Gui, Weibo Liao, Fengxiang Qin, Xi Hu, Bingyu Liang, Junjun Jiang, Jiegang Huang, Chuanyi Ning, Jiang Chen, Jianhua Ju, Jingzhen Lai, Jie Liu, Bo Zhou*, Li Ye*, Hao Liang*, Polyether antibiotics K-41A and K-41Am inhibit HIV-1 replication via suppressing the activities of HIV-1 reverse transcriptase and integrase, Arch Med Sci, 2020, 1(1): 1-12.

(4) Lin Yao^#，Li Yueqi^#，Chen Hubin^#，Meng Jun，Li Jingyi，Chu Jiemei，Zheng Ruili，Wang Hailong，Pan Peijiang，Su Jinming，Jiang Junjun，Ye Li，Liang Hao，An Sanqi*. Weighted gene co-expression network analysis revealed T cell differentiation associated with the age-related phenotypes in COVID-19 patients. BMC Medical Genomics 2023, 16:59.

(5) Sanqi An^#, Yueqi Li^#, Yao Lin^#, Jiemei Chu, Jinming Su, Qiuli Chen, Hailong Wang, Peijiang Pan, Ruili Zheng, Jingyi Li, Junjun Jiang*, Li Ye*, Hao Liang*. Genome-Wide Profiling Reveals Alternative Polyadenylation of Innate Immune-Related mRNA in Patients With COVID-19. Frontiers in Immunology, October 2021, 12.

(6) Xiaopeng Hu, Sanqi An*, Jiemei Chu, Bingyu Liang , Yanyan Liao, Junjun Jiang, Yao Lin, Li Ye* and Hao Liang. Potential Inhibitors of Monkeypox Virus Revealed by Molecular Modeling Approach to Viral DNA Topoisomerase I. Molecules. 2023, 28(3): 1444.

(7) Yaxin Chen#, Gang Wang#, Jingyi Li, Lei Xia, Lin Zhu, Wenxing Li, Qiang Luo, Yinlu Liao, Yao Lin, Liyun Bi, Hubin Chen, Jiemei Chu, Yueqi Li, Jinming Su, Li Ye, Junjun Jiang, Hao Liang*, Weimin Li* and Sanqi An*. CASA: a comprehensive da-tabase resource for the COVID-19 Alternative Splicing Atlas. Journal of Translational Medicine. 20;20(1):473. 2022.

(8) Junjun Jiang#*, Xi Hu#, Wenwei Li#, Jie Liu, Bingyu Liang, Hui Chen, Jiegang Huang, Ning Zang, Chuanyi Ning, Yanyan Liao, Rongfeng Chen, Jingzhen Lai, Jiemei Chu, Peijiang Pan, Ping Cui, Qiao Tang, Xiu Chen, Hao Liang*, Li Ye*. Enhanced Signaling Through the TLR9 Pathway Is Associated With Resistance to HIV-1 Infection in Chinese HIV-1–Exposed Seronegative Individuals. Frontiers in Immunology. 2020, 11:1050.

(9) Bingyu Liang, Qiuyu Wei, Yao Yang, Yuan Yang, Jie Liu, Jiemei Chu, Rongfeng Chen, Hao Liang, Li Ye. Identification of a Novel HIV-1 CRF55_01B/B Recombinant Isolate in Guangxi, China. AIDS Res Hum Retroviruses. 2020 May;36(5):434-439.

专利：

叶力，梁浩，刘欣，林兴，蒋俊俊，梁冰玉，周波，褚洁梅，覃凤翔，梁娜，廖炜波，胡茜。聚醚类抗生素K-41B、K-41A在制备治疗或预防艾滋病毒药物中的应用。专利申请号：CN111195246A ，2020年5月26日，中国。

软件著作权：

安三奇，李玥琪，褚洁梅，梁浩，韦吴迪，李静怡。李文兴，叶力，蒋俊俊，胡小鹏，王刚。基于m6A调控因子和序列特征的单细胞m6A计算方法软件。2022.10.21（2023SR0365699）。